Article
Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R.
PloS one - 1 Jan 2012
Passtoors Willemijn M, Boer Judith M, Goeman Jelle J, Akker Erik B van den, Deelen Joris, Zwaan Bas J, Scarborough Ann, Breggen Ruud van der, Vossen Rolf H A M, Houwing-Duistermaat Jeanine J, Ommen Gert Jan B van, Westendorp Rudi G J, van Heemst Diana, de Craen Anton J M, White Andrew J, Gunn David A, Beekman Marian, Slagboom P Eline
Abstract excerpt
The Leiden Longevity Study consists of families that express extended survival across generations, decreased morbidity in middle-age, and beneficial metabolic profiles. To identify which pathways drive this complex phenotype of familial longevity and healthy aging, we performed a genome-wide gene expression study within this cohort to screen for mRNAs whose expression changes with age and associates with...
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