Article
Effects of basic fibroblast growth factor on proliferation and phenotype expression of chondrocytes embedded in collagen gel.
General pharmacology - 1 Nov 1998
Matsusaki M, Ochi M, Uchio Y, Shu N, Kurioka H, Kawasaki K, Adachi N
Abstract excerpt
1. Whether basic fibroblast growth factor (bFGF) can stimulate proliferation and synthesis of chondroitin sulfate of chondrocytes in gel culture while maintaining the phenotype was studied. 2. At 3 weeks in culture, the cell number in 1.0 ng/ml (18.5+/-2.1 x 10(5)) and 10.0 ng/ml of the bFGF grou...
Topics
- Animals
- Cartilage, Articular
- Cell Count
- Cell Division
- Cells, Cultured
- Chondrocytes
- Chondroitin Sulfates
- Collagen
- Culture Media
- Dose-Response Relationship, Drug
- Extracellular Matrix
- Fibroblast Growth Factor 2