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Article

Induction of apoptosis in chondrocytes by tumor necrosis factor-alpha.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Sept 2001

Aizawa T, Kon T, Einhorn T A, Gerstenfeld L C

Abstract excerpt

Tumor necrosis factor alpha (TNF-alpha) induces apoptosis in a number of cell types and plays an essential role in bone remodeling, both stimulating the proliferation of osteoblasts and activating osteoclasts. During endochondral ossification, apoptosis of chondrocytes occurs concurrently with new bone formation and the resorption and replacement of mineralized cartilage with woven bone. In the present study, the...

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PMID: 11562122
DOI: 10.1016/S0736-0266(00)00078-4

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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