Article
Expression of decorin and biglycan by rabbit articular chondrocytes. Effects of cytokines and phenotypic modulation.
Biochimica et biophysica acta - 16 Jun 1998
Demoor-Fossard M, Redini F, Boittin M, Pujol J P
Abstract excerpt
In this study, the levels of mRNAs coding for aggrecan, decorin and biglycan in rabbit articular chondrocytes were investigated, using both monolayer and 3D-alginate cultures treated with TGF-beta 1 and IL-1 beta. The cells were shown to express higher amounts of proteoglycan messages, specially...
Topics
- Aggrecans
- Alginates
- Animals
- Biglycan
- Cartilage, Articular
- Cell Differentiation
- Cells, Cultured
- Chondrocytes
- Cytokines
- Decorin
- Extracellular Matrix Proteins
- Gene Expression
- Gene Expression Regulation
- Interleukin-1
- Lectins, C-Type
- Male
- Phenotype
- Proteoglycans