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Article

Expression of decorin and biglycan by rabbit articular chondrocytes. Effects of cytokines and phenotypic modulation.

Biochimica et biophysica acta - 16 Jun 1998

Demoor-Fossard M, Redini F, Boittin M, Pujol J P

Abstract excerpt

In this study, the levels of mRNAs coding for aggrecan, decorin and biglycan in rabbit articular chondrocytes were investigated, using both monolayer and 3D-alginate cultures treated with TGF-beta 1 and IL-1 beta. The cells were shown to express higher amounts of proteoglycan messages, specially the aggrecan, in gels than in monolayers. TGF-beta 1 increased aggrecan mRNA in both systems, whereas biglycan message...

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PMID: 9689917
DOI: 10.1016/s0167-4781(98)00044-x

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