Article
Tumor necrosis factor alpha activation of the apoptotic cascade in murine articular chondrocytes is associated with the induction of metalloproteinases and specific pro-resorptive factors.
Arthritis and rheumatism - 1 Oct 2003
Cho Tae-Joon, Lehmann Wolfgang, Edgar Cory, Sadeghi Cameron, Hou Andrew, Einhorn Thomas A, Gerstenfeld Louis C
Abstract excerpt
OBJECTIVE: Tumor necrosis factor alpha (TNFalpha) blockade provides substantive reduction of the symptoms of rheumatoid arthritis (RA). While the biologic actions of TNFalpha have been well characterized in immune and synovial cells, which are known to be major contributors to the progression of cartilage destruction in RA, the current studies were designed to assess the direct effects of TNFalpha on...
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