Article
The G-217A variant of the angiotensinogen gene affects basal transcription and is associated with hypertension in a Taiwanese population.
Journal of hypertension - 1 Nov 2003
Wu Shyh-Jong, Chiang Fu-Tien, Jiang Jun-Ran, Hsu Kwan-Lih, Chern Tser-Haw, Tseng Yung-Zu
Abstract excerpt
OBJECTIVE: Polymorphisms of the angiotensinogen (AGT) gene, especially in the promoter region, are in linkage concordance and are associated with hypertension. In this study, we examined the role of AGT promoter polymorphisms, including G-217A, A-6G and M235T variants, and their promoter function in essential hypertension in Taiwanese populations. DESIGN: An association study was conducted to assess the genotype...
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