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Article

A common connexin-40 gene promoter variant affects connexin-40 expression in human atria and is associated with atrial fibrillation.

Circulation. Arrhythmia and electrophysiology - 1 Feb 2011

Wirka Robert C, Gore Shamone, Van Wagoner David R, Arking Dan E, Lubitz Steven A, Lunetta Kathryn L, Benjamin Emelia J, Alonso Alvaro, Ellinor Patrick T, Barnard John, Chung Mina K, Smith Jonathan D

Abstract excerpt

BACKGROUND: A common single-nucleotide polymorphism (SNP) in the promoter of the Connexin-40 (Cx40) gene GJA5 was suggested to affect Cx40 promoter activity and the risk of atrial fibrillation (AF), but the role of other common Cx40 polymorphisms is unknown. METHODS AND RESULTS: Eight SNPs within...

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Share to Atrial Fibrillation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gap Junction alpha-5 Protein

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Source

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Identifiers

PMID: 21076161
DOI: 10.1161/CIRCEP.110.959726
PMCID: PMC3057452

Genes

GJA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21076161-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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