Article
Polymorphism of the type 6 adenylyl cyclase gene and cardiac hypertrophy.
Journal of cardiovascular pharmacology - 1 Dec 2003
Ikoma Eiko, Tsunematsu Takashi, Nakazawa Ichirou, Shiwa Tadashi, Hibi Kiyoshi, Ebina Toshiaki, Mochida Yasuyuki, Toya Yoshiyuki, Hori Hideaki, Uchino Kazuaki, Minamisawa Susumu, Kimura Kazuo, Umemura Satoshi, Ishikawa Yoshihiro
Abstract excerpt
We investigated whether polymorphism of the type 6 adenylyl cyclase gene influences the occurrence of left ventricular hypertrophy in a Japanese population. Type 6 adenylyl cyclase is a major cardiac adenylyl cyclase isoform and plays an important role in regulating cardiac function. We examined the type 6 adenylyl cyclase gene for single nucleotide polymorphism by heteroduplex analysis and found a mutation...
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