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Article

The role of osteopontin (OPN/SPP1) haplotypes in the susceptibility to Crohn's disease.

PloS one - 1 Jan 2011

Glas Jürgen, Seiderer Julia, Bayrle Corinna, Wetzke Martin, Fries Christoph, Tillack Cornelia, Olszak Torsten, Beigel Florian, Steib Christian, Friedrich Matthias, Diegelmann Julia, Czamara Darina, Brand Stephan

Abstract excerpt

BACKGROUND: Osteopontin represents a multifunctional molecule playing a pivotal role in chronic inflammatory and autoimmune diseases. Its expression is increased in inflammatory bowel disease (IBD). The aim of our study was to analyze the association of osteopontin (OPN/SPP1) gene variants in a large cohort of IBD patients. METHODOLOGY/PRINCIPAL FINDINGS: Genomic DNA from 2819 Caucasian individuals (n = 841...

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Share to Colitis, Ulcerative
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22242114
DOI: 10.1371/journal.pone.0029309
PMCID: PMC3248444

Genes

SPP1

Variants

rs1126616
rs2728127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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