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Article

Switching between raltegravir resistance pathways analyzed by deep sequencing.

AIDS (London, England) - 23 Oct 2011

Mukherjee Rithun, Jensen Shane T, Male Frances, Bittinger Kyle, Hodinka Richard L, Miller Michael D, Bushman Frederic D

Abstract excerpt

OBJECTIVE: Our objective was to analyze the pathways leading to resistance of HIV to the integrase (IN) inhibitor raltegravir (RAL). DESIGN: Three HIV-infected individuals exhibiting RAL resistance pathway switching were characterized using longitudinal analysis of viral samples from plasma. METHODS: 454/Roche pyrosequencing was used to generate approximately 74,000 sequence reads from the integrase coding...

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Source

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Identifiers

PMID: 21832937
DOI: 10.1097/QAD.0b013e32834b34de
PMCID: PMC3368328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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