Article
Quadruplex-single nucleotide polymorphisms (Quad-SNP) influence gene expression difference among individuals.
Nucleic acids research - 1 May 2012
Baral Aradhita, Kumar Pankaj, Halder Rashi, Mani Prithvi, Yadav Vinod Kumar, Singh Ankita, Das Swapan K, Chowdhury Shantanu
Abstract excerpt
Non-canonical guanine quadruplex structures are not only predominant but also conserved among bacterial and mammalian promoters. Moreover recent findings directly implicate quadruplex structures in transcription. These argue for an intrinsic role of the structural motif and thereby posit that single nucleotide polymorphisms (SNP) that compromise the quadruplex architecture could influence function. To test this,...
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