Article
Genome-wide association for fear conditioning in an advanced intercross mouse line.
Behavior genetics - 1 May 2012
Parker Clarissa C, Sokoloff Greta, Cheng Riyan, Palmer Abraham A
Abstract excerpt
Fear conditioning (FC) may provide a useful model for some components of post-traumatic stress disorder (PTSD). We used a C57BL/6J × DBA/2J F(2) intercross (n = 620) and a C57BL/6J × DBA/2J F(8) advanced intercross line (n = 567) to fine-map quantitative trait loci (QTL) associated with FC. We conducted an integrated genome-wide association analysis in QTLRel and identified five highly significant QTL affecting...
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