An investigation of modifying effects of single nucleotide polymorphisms in metabolism-related genes on the relationship between peripheral nerve function and mercury levels in urine and hair.

doi:10.1016/j.scitotenv.2011.12.019

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Article

An investigation of modifying effects of single nucleotide polymorphisms in metabolism-related genes on the relationship between peripheral nerve function and mercury levels in urine and hair.

The Science of the total environment - 15 Feb 2012

Wang Yi, Goodrich Jaclyn M, Werner Robert, Gillespie Brenda, Basu Niladri, Franzblau Alfred

Abstract excerpt

Mercury (Hg) is a potent neurotoxicant. We hypothesized that single nucleotide polymorphisms (SNPs) in genes coding glutathione-related proteins, selenoproteins and metallothioneins may modify the relationship of mercury biomarkers with changes in peripheral nerve function. Dental professionals (n=515) were recruited in 2009 and 2010. Sensory nerve function (onset latency, peak latency and amplitude) of the...

Topics

DNA
Dental Assistants
Dentists
Female
Genotype
Glutathione
Hair
Humans
Linear Models
Male
Mercury
Mercury Poisoning, Nervous System
Metallothionein
Middle Aged

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multivariate Analysis

Neural Conduction

Occupational Diseases

Occupational Exposure

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Identifiers

PMID: 22236634
DOI: 10.1016/j.scitotenv.2011.12.019
PMCID: PMC3299006

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