The association between a genetic polymorphism of coproporphyrinogen oxidase, dental mercury exposure and neurobehavioral response in humans.

doi:10.1016/j.ntt.2005.10.006

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Article

The association between a genetic polymorphism of coproporphyrinogen oxidase, dental mercury exposure and neurobehavioral response in humans.

Neurotoxicology and teratology - 1 Jan 2000

Echeverria Diana, Woods James S, Heyer Nicholas J, Rohlman Dianne, Farin Federico M, Li Tingting, Garabedian Claire E

Abstract excerpt

We previously described a polymorphism in exon 4 of the gene encoding the heme biosynthetic pathway enzyme, coproporphyrinogen oxidase (CPOX4), which significantly modifies the effect of mercury exposure on urinary porphyrin excretion in humans. Here, we examined potential consequences of this polymorphism ("CPOX4") on performance within neurobehavioral domains, symptoms, and mood that are known to be affected by...

Topics

Adult
Behavioral Symptoms
Cognition Disorders
Coproporphyrinogen Oxidase
DNA Mutational Analysis
Dentistry
Depressive Disorder
Female
Genetic Predisposition to Disease
Genetic Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Male

Mercury

Mercury Poisoning, Nervous System

Middle Aged

Neuropsychological Tests

Occupational Exposure

Source

Open in PubMed

Identifiers

PMID: 16343843
DOI: 10.1016/j.ntt.2005.10.006

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