Article
Mercury neurotoxicity is associated with polymorphisms inTNF-αandMMP-2genes in the Munduruku indigenous population of the Brazilian Amazon.
Neurotoxicology - 1 Sept 2026
Perini Jamila Alessandra, da Silva Mayara Calixto, Pessoa-Silva Felipe Oliveira, Machado Daniel Escorsim, Cardoso Alexander Machado, Louvem Júlia Maretti, de Oliveira d'El Rei Pinto Daniel, de Oliveira Rogério Adas Ayres, de Vasconcellos Ana Claudia Santiago, Basta Paulo Cesar
Abstract excerpt
Exposure to mercury (Hg) is associated with neurological disorders. Polymorphisms in genes involved in the toxicokinetic and toxicodynamic of Hg may be associated with susceptibility to adverse neurological effects of Hg. This study examined the relationship between polymorphisms in TNF-α (rs1799964, rs1799724 and rs1800629), IL-6 (rs1800795) and MMP-2 (rs2285053) with Hg levels and neurological impact in the...