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Article

Glutathione-related genetic polymorphisms are associated with mercury retention and nephrotoxicity in gold-mining settings of a Colombian population.

Scientific reports - 22 Apr 2021

Medina Pérez Olga Marcela, Flórez-Vargas Oscar, Rincón Cruz Giovanna, Rondón González Fernando, Rocha Muñoz Linda, Sánchez Rodríguez Luz Helena

Abstract excerpt

Mercury (Hg) vapor can produce kidney injury, where the proximal tubule region of the nephron is the main target of the Hg-induced oxidative stress. Hg is eliminated from the body as a glutathione conjugate. Thus, single nucleotide polymorphisms (SNPs) in glutathione-related genes might modulate the negative impact of this metal on the kidneys. Glutathione-related SNPs were tested for association with levels of...

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PMID: 33888803
DOI: 10.1038/s41598-021-88137-3
PMCID: PMC8062595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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