Article
An investigation of modifying effects of metallothionein single-nucleotide polymorphisms on the association between mercury exposure and biomarker levels.
Environmental health perspectives - 1 Apr 2012
Wang Yi, Goodrich Jaclyn M, Gillespie Brenda, Werner Robert, Basu Niladri, Franzblau Alfred
Abstract excerpt
BACKGROUND: Recent studies have suggested that several genes that mediate mercury metabolism are polymorphic in humans. OBJECTIVE: We hypothesized that single-nucleotide polymorphisms (SNPs) in metallothionein (MT) genes may underlie interindividual differences in mercury biomarker levels. We studied the potential modifying effects of MT SNPs on mercury exposure-biomarker relationships. METHODS: We measured total...
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