Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion

Abstract excerpt

BACKGROUND: Carcinoma cells must circumvent the normally suppressive signals to disseminate. While often considered 'stop' signals for adherent cells, CXCR3-binding chemokines have recently been correlated positively with cancer progression though the molecular basis remains unclear. RESULTS: Here, we examined the expression and function of two CXCR3 variants in human prostate cancer biopsies and cell lines....