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Article

PAX3 and FOXD3 Promote CXCR4 Expression in Melanoma

23 Jul 2015

Abstract excerpt

Metastatic melanoma is an aggressive and deadly disease. The chemokine receptor CXCR4 is active in melanoma metastasis, although the mechanism for the promotion and maintenance of CXCR4 expression in these cells is mostly unknown. Here, we find melanoma cells express two CXCR4 isoforms, the common version and a variant that is normally restricted to cells during development or to mature blood cells. CXCR4...

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PMID: 26205821
DOI: 10.1074/jbc.m115.670976

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