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Article

Expression of CXCR4 and CXCL12 (SDF‐1) in human prostate cancers (PCa) in vivo

15 Apr 2003

Abstract excerpt

Human prostate cancers (PCa) express great variability in their ability to metastasize to bone. The identification of molecules associated with aggressive phenotypes will help to define PCa subsets and will ultimately lead to better treatment strategies. The chemokine stromal-derived factor-1 (SDF-1 or CXCL12) and its receptor CXCR4 are now known to modulate the migration and survival of an increasing array of...

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PMID: 12761880
DOI: 10.1002/jcb.10522

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