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Article

Expression and activation of alpha v beta 3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells.

The Prostate - 1 Jan 2007

Sun Yan-Xi, Fang Ming, Wang Jianhua, Cooper Carlton R, Pienta Kenneth J, Taichman Russell S

Abstract excerpt

BACKGROUND: Stromal cell-derived factor-1 (SDF-1 or CXCL12) and CXCR4 are key elements in the metastasis of prostate cancer cells to bone--but the mechanisms as to how it localizes to the marrow remains unclear. METHODS: Prostate cancer cell lines were stimulated with SDF-1 and evaluated for alterations in the expression of adhesion molecules using microarrays, FACs, and Western blotting to identify...

Read the complete abstract on PubMed

Topics

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Share to Bone Neoplasms
Share to Cell Adhesion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chemokine CXCL12

Share to Chemokines, CXC

Share to Integrin alphaVbeta3

Share to Neoplasm Invasiveness

Share to Prostatic Neoplasms

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 17034033
DOI: 10.1002/pros.20500

Genes

CXCL12
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Expression and activation of alpha v beta 3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells.PMID 17034033Read ↗

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