Article
Expression and activation of alpha v beta 3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells.
The Prostate - 1 Jan 2007
Sun Yan-Xi, Fang Ming, Wang Jianhua, Cooper Carlton R, Pienta Kenneth J, Taichman Russell S
Abstract excerpt
BACKGROUND: Stromal cell-derived factor-1 (SDF-1 or CXCL12) and CXCR4 are key elements in the metastasis of prostate cancer cells to bone--but the mechanisms as to how it localizes to the marrow remains unclear. METHODS: Prostate cancer cell lines were stimulated with SDF-1 and evaluated for alterations in the expression of adhesion molecules using microarrays, FACs, and Western blotting to identify...
Topics
- Bone Neoplasms
- Cell Adhesion
- Cell Line, Tumor
- Chemokine CXCL12
- Chemokines, CXC
- Gene Expression Regulation, Neoplastic
- Humans
- Integrin alphaVbeta3
- Male
- Neoplasm Invasiveness
- Phenotype
- Phosphorylation
- Prostatic Neoplasms
- Protein Binding