Article
[On the possibility of patient phenotyping on the basis of cytochrome p-450 1A2 isoenzyme activity using caffeine as the test substrate].
Eksperimental'naia i klinicheskaia farmakologiia - 1 Jan 2000
Filimonova A A, Ziganshina L E, Ziganshin A U, Chichirov A A
Abstract excerpt
Reactions of caffeine biotransformation and enzymes participating in the caffeine metabolism via the paraxanthine pathway are reviewed. Data on the drugs metabolized mainly in cytochrome P-450 1A2 isoenzyme (CYP 1A2) are analyzed. Information on the phenotypes of CYP 1A2 activity in smoking healthy volunteers, women using oral contraceptives, diabetes patients, those with liver disorders, etc. is summarized....
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