Article
Variation within the Huntington's disease gene influences normal brain structure.
PloS one - 1 Jan 2012
Mühlau Mark, Winkelmann Juliane, Rujescu Dan, Giegling Ina, Koutsouleris Nikolaos, Gaser Christian, Arsic Milan, Weindl Adolph, Reiser Maximilian, Meisenzahl Eva M
Abstract excerpt
Genetics of the variability of normal and diseased brain structure largely remains to be elucidated. Expansions of certain trinucleotide repeats cause neurodegenerative disorders of which Huntington's disease constitutes the most common example. Here, we test the hypothesis that variation within the IT15 gene on chromosome 4, whose expansion causes Huntington's disease, influences normal human brain structure. In...
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