Article
Trinucleotide repeat length and clinical progression in Huntington's disease.
Neurology - 1 Feb 1996
Brandt J, Bylsma F W, Gross R, Stine O C, Ranen N, Ross C A
Abstract excerpt
We examined the relationship between length of the trinucleotide (CAG) repeat at IT-15 and clinical progression of Huntington's disease in 46 mildly to moderately affected patients over a 2-year interval. Patients were divided into those with short mutations (37 to 46 repeats; n = 25) and those with long mutations (> or = 47 repeats; n = 21). Patients with long repeat lengths had earlier age at onset and were...
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