Article
Trinucleotide repeat length and clinical progression in Huntington's disease.
Neurology - 1 Feb 1996
Brandt J, Bylsma F W, Gross R, Stine O C, Ranen N, Ross C A
Abstract excerpt
We examined the relationship between length of the trinucleotide (CAG) repeat at IT-15 and clinical progression of Huntington's disease in 46 mildly to moderately affected patients over a 2-year interval. Patients were divided into those with short mutations (37 to 46 repeats; n = 25) and those w...
Topics
- Activities of Daily Living
- Adult
- Age of Onset
- Analysis of Variance
- Base Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 4
- DNA Primers
- Disease Progression
- Humans
- Huntington Disease
- Longitudinal Studies
- Molecular Sequence Data
- Mutation
- Neurologic Examination
- Neuropsychological Tests
- Polymerase Chain Reaction
- Time Factors