Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Huntington's disease gene: Regional and cellular expression in brain of normal and affected individuals

1 Feb 1995

Abstract excerpt

Huntington's disease (HD) is an autosomal dominant disorder characterized by involuntary movements, dementia, and progressive, global, but regionally accentuated, brain atrophy. The disease affects the striatum most severely. An expansion of a trinucleotide repeat on chromosome 4p16.3 within the coding region of a gene termed IT15 has been identified as the mutation causing HD. The normal function of IT15 and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Neurodegenerative Diseases
Share to Mitochondrial Function and Pathology
Share to Neurological disorders and treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7847863
DOI: 10.1002/ana.410370213

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Huntington's disease gene: Regional and cellular expression in brain of normal and affected individualsPMID 7847863Read ↗

Expression of the Huntington's disease (IT15) protein product in HD patients.Semantic proximity Read ↗

Differential distribution of the normal and mutated forms of huntingtin in the human brain.Semantic proximity Read ↗

Huntington's disease gene (IT15) is widely expressed in human and rat tissuesSemantic proximity Read ↗

Expression of the mutant allele of IT-15 (the HD gene) in striatum and cortex of Huntington's disease patients.Semantic proximity Read ↗

Widespread expression of Huntington's disease gene (IT15) protein productSemantic proximity Read ↗

Huntington disease: a single-gene degenerative disorder of the striatumSemantic proximity Read ↗

Regional and cellular gene expression changes in human Huntington's disease brainSemantic proximity Read ↗

Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies.Semantic proximity Read ↗

Intranuclear Neuronal Inclusions in Huntington's Disease and Dentatorubral and Pallidoluysian Atrophy: Correlation between the Density of Inclusions andIT15CAG Triplet Repeat LengthSemantic proximity Read ↗

The selective vulnerability of nerve cells in Huntington's diseaseSemantic proximity Read ↗

Scn4b Modulates Huntington’s Disease Phenotype Severity in vivoSemantic proximity Read ↗

Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.