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Article

Tandem repeat polymorphisms are associated with brain structure: results of two large population-based studies.

Genome medicine - 6 Jul 2026

Mantey Richard, Hu Jialu, Touhidinia Maryam, Butt Tanzeem, Sidky Ahmed Mokhtar, Sobhani Roohollah, Estrada Santiago, Haendler Kristian, De Domenico Elena, Beyer Marc Daniel, Breteler Monique Maria Bernadette, Aziz Nasir Ahmad

Abstract excerpt

BACKGROUND: Although genome-wide association studies (GWAS) have uncovered many genetic variants linked to brain structure, much of its heritability still remains unexplained. Short tandem repeats (STRs) are rarely considered in GWAS but may account for part of this "missing heritability". While the causal association of large pathogenic repeat expansions with a range of brain disorders is well established, the...

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Identifiers

PMID: 42410459
DOI: 10.1186/s13073-026-01702-1
PMCID: PMC13335240

Genes

NADK
PRR14L

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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