Article

Huntingtin CAG repeat is a continuous modifier of brain structure and health vulnerability

2026-05-12

Abstract excerpt

Huntington’s disease is caused by a CAG repeat expansion in the Huntingtin gene ( HTT ) above a pathogenic threshold; however, the biological consequences of repeat-length variation below this threshold remain poorly understood. Using whole-genome sequencing and linked phenotypic data from UK Biobank participants, we show that repeat-length variation within the normal and intermediate range is associated with mea...

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Identifiers and source

Literature Corpus work: 3517483f-897a-5cee-b6e3-69ec481dcc01
DOI: 10.64898/2026.05.08.26352223

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