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Article

Sex‐specific effects of the Huntington gene on normal neurodevelopment

7 Nov 2016

Abstract excerpt

Huntington disease is a neurodegenerative disorder caused by a gene (HTT) with a unique feature of trinucleotide repeats ranging from 10 to 35 in healthy people; when expanded beyond 39 repeats, Huntington disease develops. Animal models demonstrate that HTT is vital to brain development; however, this has not been studied in humans. Moreover, evidence suggests that triplet repeat genes may have been vital in...

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PMID: 27870408
DOI: 10.1002/jnr.23980

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