Article
Correlations between triplet repeat expansion and clinical features in Huntington's disease.
Archives of neurology - 1 Aug 1995
Claes S, Van Zand K, Legius E, Dom R, Malfroid M, Baro F, Godderis J, Cassiman J J
Abstract excerpt
OBJECTIVE: To investigate possible correlations between the length of the (CAG)n trinucleotide repeat in Hungtington's disease gene IT15 and clinical features (age at onset, symptoms at onset, and mode of progression) in Huntington's disease. DESIGN: In 59 patients with Huntington's disease, the expansion of the (CAG)n trinucleotide repeat was determined and clinical data were obtained retrospectively. SETTING:...
Topics
- Age Factors
- Alleles
- Humans
- Huntington Disease
- Middle Aged
- Repetitive Sequences, Nucleic Acid