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Article

High-resolution genomic profiling of adult and pediatric core-binding factor acute myeloid leukemia reveals new recurrent genomic alterations.

Blood - 8 Mar 2012

Kühn Michael W M, Radtke Ina, Bullinger Lars, Goorha Salil, Cheng Jinjun, Edelmann Jennifer, Gohlke Juliane, Su Xiaoping, Paschka Peter, Pounds Stanley, Krauter Jürgen, Ganser Arnold, Quessar Asmaa, Ribeiro Raul, Gaidzik Verena I, Shurtleff Sheila, Krönke Jan, Holzmann Karlheinz, Ma Jing, Schlenk Richard F, Rubnitz Jeffrey E, Döhner Konstanze, Döhner Hartmut, Downing James R

Abstract excerpt

To identify cooperating lesions in core-binding factor acute myeloid leukemia, we performed single-nucleotide polymorphism-array analysis on 300 diagnostic and 41 relapse adult and pediatric leukemia samples. We identified a mean of 1.28 copy number alterations per case at diagnosis in both patie...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Leukemic

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Share to Loss of Heterozygosity

Share to Oncogene Proteins, Fusion

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Source

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Identifiers

PMID: 22234698
DOI: 10.1182/blood-2011-09-380444
PMCID: PMC3311263

Genes

LSAMP
NRAS
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22234698-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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