Genomic heterogeneity in core-binding factor acute myeloid leukemia and its clinical implication.

doi:10.1182/bloodadvances.2020002673

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genomic heterogeneity in core-binding factor acute myeloid leukemia and its clinical implication.

Blood advances - 22 Dec 2020

Jahn Nikolaus, Terzer Tobias, Sträng Eric, Dolnik Anna, Cocciardi Sibylle, Panina Ekaterina, Corbacioglu Andrea, Herzig Julia, Weber Daniela, Schrade Anika, Götze Katharina, Schröder Thomas, Lübbert Michael, Wellnitz Dominique, Koller Elisabeth, Schlenk Richard F, Gaidzik Verena I, Paschka Peter, Rücker Frank G, Heuser Michael, Thol Felicitas, Ganser Arnold, Benner Axel, Döhner Hartmut, Bullinger Lars, Döhner Konstanze

Abstract excerpt

Core-binding factor (CBF) acute myeloid leukemia (AML) encompasses AML with inv(16)(p13.1q22) and AML with t(8;21)(q22;q22.1). Despite sharing a common pathogenic mechanism involving rearrangements of the CBF transcriptional complex, there is growing evidence for considerable genotypic heterogeneity. We comprehensively characterized the mutational landscape of 350 adult CBF-AML [inv(16): n = 160, t(8;21): n =...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cancer Genomics and Diagnostics

Share to Core Binding Factors

Share to Epigenetics and DNA Methylation

Share to Genomics

Share to Leukemia, Myeloid, Acute

Share to Mutation

Share to Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 33351131
DOI: 10.1182/bloodadvances.2020002673
PMCID: PMC7757000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic heterogeneity in core-binding factor acute myeloid leukemia and its clinical implication.PMID 33351131Read ↗

Comprehensive mutational profiling of core binding factor acute myeloid leukemia.Semantic proximity Read ↗

The genomic landscape of core-binding factor acute myeloid leukemias.Semantic proximity Read ↗

Advances in molecular genetics and treatment of core-binding factor acute myeloid leukemiaSemantic proximity Read ↗

Comprehensive Mutation Profile in Acute Myeloid Leukemia Patients with RUNX1-RUNX1T1 or CBFB-MYH11 FusionsSemantic proximity Read ↗

Core Binding Factor AML Beyond Favorable Risk: Molecular Heterogeneity, MRD Dynamics, and Implications for Clinical Decision-MakingSemantic proximity Read ↗

Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia.Semantic proximity Read ↗

Genetic abnormalities in core binding factor acute myeloid leukemia.Semantic proximity Read ↗

Core‐binding factor acute myeloid leukemia: Heterogeneity, monitoring, and therapySemantic proximity Read ↗

Core-Binding Factor Acute Myeloid LeukemiaSemantic proximity Read ↗

Modeling interactions between leukemia-specific chromosomal changes, somatic mutations, and gene expression patterns during progression of core-binding factor leukemias.Semantic proximity Read ↗

Genetic abnormalities predict outcomes in patients with core binding factor acute myeloid leukemiaSemantic proximity Read ↗

A multi-omic single-cell landscape reveals transcription and epigenetic regulatory features of t(8;21) AMLSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.