Article
High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations.
Blood - 6 Dec 2012
Edelmann Jennifer, Holzmann Karlheinz, Miller Florian, Winkler Dirk, Bühler Andreas, Zenz Thorsten, Bullinger Lars, Kühn Michael W M, Gerhardinger Andreas, Bloehdorn Johannes, Radtke Ina, Su Xiaoping, Ma Jing, Pounds Stanley, Hallek Michael, Lichter Peter, Korbel Jan, Busch Raymonde, Mertens Daniel, Downing James R, Stilgenbauer Stephan, Döhner Hartmut
Abstract excerpt
To identify genomic alterations in chronic lymphocytic leukemia (CLL), we performed single-nucleotide polymorphism-array analysis using Affymetrix Version 6.0 on 353 samples from untreated patients entered in the CLL8 treatment trial. Based on paired-sample analysis (n = 144), a mean of 1.8 copy number alterations per patient were identified; approximately 60% of patients carried no copy number alterations other...
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