Genomic characterization of AML with aberrations of chromosome 7: a multinational cohort of 519 patients.

doi:10.1186/s13045-024-01590-1

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Article

Genomic characterization of AML with aberrations of chromosome 7: a multinational cohort of 519 patients.

Journal of hematology & oncology - 19 Aug 2024

Halik Adriane, Tilgner Marlon, Silva Patricia, Estrada Natalia, Altwasser Robert, Jahn Ekaterina, Heuser Michael, Hou Hsin-An, Pratcorona Marta, Hills Robert K, Metzeler Klaus H, Fenwarth Laurene, Dolnik Anna, Terre Christine, Kopp Klara, Blau Olga, Szyska Martin, Christen Friederike, Krönke Jan, Vasseur Loïc, Löwenberg Bob, Esteve Jordi, Valk Peter J M, Duchmann Matthieu, Chou Wen-Chien, Linch David C, Döhner Hartmut, Gale Rosemary E, Döhner Konstanze, Bullinger Lars, Yoshida Kenichi, Damm Frederik

Abstract excerpt

BACKGROUND: Deletions and partial losses of chromosome 7 (chr7) are frequent in acute myeloid leukemia (AML) and are linked to dismal outcome. However, the genomic landscape and prognostic impact of concomitant genetic aberrations remain incompletely understood. METHODS: To discover genetic lesions in adult AML patients with aberrations of chromosome 7 [abn(7)], 60 paired diagnostic/remission samples were...

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PMID: 39160538
DOI: 10.1186/s13045-024-01590-1
PMCID: PMC11331663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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