Article
Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP).
Blood - 3 Sept 2009
Iacobucci Ilaria, Storlazzi Clelia Tiziana, Cilloni Daniela, Lonetti Annalisa, Ottaviani Emanuela, Soverini Simona, Astolfi Annalisa, Chiaretti Sabina, Vitale Antonella, Messa Francesca, Impera Luciana, Baldazzi Carmen, D'Addabbo Pietro, Papayannidis Cristina, Lonoce Angelo, Colarossi Sabrina, Vignetti Marco, Piccaluga Pier Paolo, Paolini Stefania, Russo Domenico, Pane Fabrizio, Saglio Giuseppe, Baccarani Michele, Foà Robin, Martinelli Giovanni
Abstract excerpt
The BCR-ABL1 fusion gene defines the subgroup of acute lymphoblastic leukemia (ALL) with the worst clinical prognosis. To identify oncogenic lesions that combine with BCR-ABL1 to cause ALL, we used Affymetrix Genome-Wide Human SNP arrays (250K NspI and SNP 6.0), fluorescence in situ hybridization, and genomic polymerase chain reaction to study 106 cases of adult BCR-ABL1-positive ALL. The most frequent somatic...
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