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Article

LRET Determination of Molecular Distances during pH Gating of the Mammalian Inward Rectifier Kir1.1b.

Biophysical journal - 9 Jan 2018

Nanazashvili Mikheil, Sánchez-Rodríguez Jorge E, Fosque Ben, Bezanilla Francisco, Sackin Henry

Abstract excerpt

Gating of the mammalian inward rectifier Kir1.1 at the helix bundle crossing (HBC) by intracellular pH is believed to be mediated by conformational changes in the C-terminal domain (CTD). However, the exact motion of the CTD during Kir gating remains controversial. Crystal structures and single-molecule fluorescence resonance energy transfer of KirBac channels have implied a rigid body rotation and/or a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29320699
DOI: 10.1016/j.bpj.2017.10.044
PMCID: PMC5773755

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