Early brain amyloidosis in APP/PS1 mice with serum insulin-like growth factor-I deficiency.

doi:10.1016/j.neulet.2011.12.048

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Article

Early brain amyloidosis in APP/PS1 mice with serum insulin-like growth factor-I deficiency.

Neuroscience letters - 16 Feb 2012

Poirier R, Fernandez A M, Torres-Aleman I, Metzger F

Abstract excerpt

The influence of insulin-like growth factor I (IGF-I) on the progression of Alzheimer's disease (AD) is discussed controversially. To help clarify the role of this circulating neurotrophic factor in brain amyloidosis, the major pathological trait in AD, we analyzed plaque formation in a mouse model of AD transgenic for human APP and PS1 mutations with reduced serum IGF-I levels (LIDAD mice). We found that brain...

Topics

Age of Onset
Aging
Alzheimer Disease
Amyloid beta-Protein Precursor
Amyloidosis
Animals
Brain
Female
Gliosis
Humans
Inflammation
Insulin-Like Growth Factor I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Transgenic

Mutation

Presenilin-1

Time Factors

Source

Open in PubMed

Identifiers

PMID: 22230888
DOI: 10.1016/j.neulet.2011.12.048

Genes

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22230888-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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