Article
Amyloid and tau pathology of familial Alzheimer's disease APP/PS1 mouse model in a senescence phenotype background (SAMP8).
Age (Dordrecht, Netherlands) - 1 Feb 2015
Porquet D, Andrés-Benito P, Griñán-Ferré C, Camins A, Ferrer I, Canudas A M, Del Valle J, Pallàs Mercè
Abstract excerpt
The amyloid precursor protein/presenilin 1 (APP/PS1) mouse model of Alzheimer's disease (AD) has provided robust neuropathological hallmarks of familial AD-like pattern at early ages, whereas senescence-accelerated mouse prone 8 (SAMP8) has a remarkable early senescence phenotype with pathological similarities to AD. The aim of this study was the investigation and characterization of cognitive and...
Topics
- Aging
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Disease Models, Animal
- Mice
- Mice, Transgenic
- Phenotype
- Presenilin-1
- tau Proteins