Article
DNA polymorphisms of the KiSS1 3' untranslated region interfere with the folding of a G-rich sequence into G-quadruplex.
Molecular and cellular endocrinology - 4 Apr 2012
Huijbregts Lukas, Roze Catherine, Bonafe Giulia, Houang Muriel, Le Bouc Yves, Carel Jean-Claude, Leger Juliane, Alberti Patrizia, de Roux Nicolas
Abstract excerpt
KISS1R and its ligand, the kisspeptins, are key hypothalamic factors that regulate GnRH hypothalamic secretion and therefore the pubertal timing. During studies analysing KiSS1 as a candidate gene in pubertal onset disorders, two SNP and one nucleotide insertion were observed in a 23 nucleotides G-rich sequence located 65 nucleotides downstream of the stop codon. The polymorphisms formed four haplotypes....
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