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Article

rs4889 and rs5782018 polymorphisms of KISS1 gene as genetic predisposing factor for PCOS in Indonesian women.

F1000Research - 1 Jan 2025

Pratama Gita, R Febri Ririn, Maidarti Mila, Wiweko Budi, Asmarinah, S Widyahening Indah, Andraini Trinovita, Bayuaji Hartanto, Hestiantoro Andon, Pangestu Mulyoto

Abstract excerpt

Background: Dysregulation of the HPG axis in PCOS causes increased frequency and amplitude of gonadotropin-releasing hormone (GnRH) pulsatility in the hypothalamus. Single nucleotide polymorphisms (SNPs) in the KISS1 gene may be associated with altered neuroendocrine signaling in PCOS. The present study aims to evaluate the association between two KISS1 polymorphisms (rs4889 and rs5780218), their haplotypes, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42158299
DOI: 10.12688/f1000research.168971.2
PMCID: PMC13182897

Genes

KISS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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