Article
Variants in the Kisspeptin-GnRH Pathway Modulate the Hormonal Profile and Reproductive Outcomes.
DNA and cell biology - 1 Jun 2020
Martins Trevisan Camila, Naslavsky Michel Satya, Monfardini Frederico, Wang Jaqueline, Zatz Mayana, Peluso Carla, Pellegrino Renata, Mafra Fernanda, Hakonarson Hakon, Ferreira Frederico Moraes, Nakaya Helder, Christofolini Denise Maria, Montagna Erik, Crandall Keith A, Barbosa Caio Parente, Bianco Bianca
Abstract excerpt
Kisspeptin has been identified as a key regulatory protein in the release of gonadotropin-releasing hormone (GnRH), which subsequently increases gonadotropin secretion during puberty to establish reproductive function and regulate the hypothalamic-pituitary-gonadal axis. The effects of variants in the KISS1, KISS1R, and GNRHR genes and their possible association with assisted reproduction outcomes remain to be...
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