Article
Influence of the pfmdr1 Gene on In Vitro Sensitivities of Piperaquine in Thai Isolates of Plasmodium falciparum.
The American journal of tropical medicine and hygiene - 1 Mar 2017
Mungthin Mathirut, Watanatanasup Ekularn, Sitthichot Naruemon, Suwandittakul Nantana, Khositnithikul Rommanee, Ward Stephen A
Abstract excerpt
Piperaquine combined with dihydroartemisinin is one of the artemisinin derivative combination therapies, which can replace artesunate-mefloquine in treating uncomplicated falciparum malaria in Thailand. The aim of this study was to determine the in vitro sensitivity of Thai Plasmodium falciparum isolates against piperaquine and the influence of the pfmdr1 gene on in vitro response. One hundred and thirty-seven...
Topics
- Alleles
- Antimalarials
- Artemisinins
- Chloroquine
- Drug Resistance
- Gene Dosage
- Genotyping Techniques
- Inhibitory Concentration 50
- Membrane Transport Proteins
- Multidrug Resistance-Associated Proteins
- Plasmodium falciparum
- Polymorphism, Single Nucleotide