Article
The prognostic significance of TP53 mutations in Chinese patients with chronic lymphocytic leukemia is independent of del(17p13).
Annals of hematology - 1 Jun 2011
Dong Hua-Jie, Zhou Li-Tao, Zhu Dan-Xia, Wang Dong-Mei, Fang Cheng, Zhu Hua-Yuan, Zhuang Yun, Miao Kou-Rong, Xu Wei, Li Jian-Yong
Abstract excerpt
The poor prognosis of chronic lymphocytic leukemia (CLL) patients with del(17p13) is well established. Several studies have shown that cases with TP53 mutations and TP53 mutations without del(17p13) may be adverse prognostic factors. We studied 173 well-characterized CLL patients by direct sequencing to detect TP53 mutations (exons 2-11). TP53 mutations were detected in 14.5% (25 of 173) of samples. Most patients...
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