Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2009

Rossi Davide, Cerri Michaela, Deambrogi Clara, Sozzi Elisa, Cresta Stefania, Rasi Silvia, De Paoli Lorenzo, Spina Valeria, Gattei Valter, Capello Daniela, Forconi Francesco, Lauria Francesco, Gaidano Gianluca

Abstract excerpt

PURPOSE: Del17p13 predicts poor outcome and chemorefractoriness in chronic lymphocytic leukemia (CLL). Conversely, it is unknown whether TP53 mutations carry any prognostic value independent of del17p13. We tested the independent prognostic value of TP53 mutations in CLL. EXPERIMENTAL DESIGN: The study was based on a consecutive series of 308 CLL. DNA sequencing of TP53 exons 2 to 10 and del17p13 interphase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Chromosome Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 17

Share to Drug Resistance, Neoplasm

Share to Genes, p53

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Mutation

Share to Prognosis

Source

Identifiers

PMID: 19188171
DOI: 10.1158/1078-0432.CCR-08-1630

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness.PMID 19188171Read ↗

Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up.Semantic proximity Read ↗

TP53 mutation and survival in chronic lymphocytic leukemia.Semantic proximity Read ↗

The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype.Semantic proximity Read ↗

The prognostic significance of TP53 mutations in Chinese patients with chronic lymphocytic leukemia is independent of del(17p13).Semantic proximity Read ↗

TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia.Semantic proximity Read ↗

Survival of Del17p CLL Depends on Genomic Complexity and Somatic Mutation.Semantic proximity Read ↗

TP53 Mutations with Low Variant Allele Frequency Predict Short Survival in Chronic Lymphocytic Leukemia.Semantic proximity Read ↗

Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in chronic lymphocytic leukemia.Semantic proximity Read ↗

Complex TP53 Alterations with del(17p) and del(13q) in Chronic Lymphocytic Leukemia: Clinical Implications from a Case-Based Review.Semantic proximity Read ↗

Relevance of TP53 for CLL diagnosticsSemantic proximity Read ↗

ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia—update on methodological approaches and results interpretationSemantic proximity Read ↗

Differential prognosis of single and multiple TP53 abnormalities in high-count MBL and untreated CLL.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.