Article
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
Carcinogenesis - 1 Mar 2012
Tao Sha, Wang Zhong, Feng Junjie, Hsu Fang-Chi, Jin Guangfu, Kim Seong-Tae, Zhang Zheng, Gronberg Henrik, Zheng Lilly S, Isaacs William B, Xu Jianfeng, Sun Jielin
Abstract excerpt
Genome-wide association studies (GWAS) have identified ∼30 single-nucleotide polymorphisms (SNPs) consistently associated with prostate cancer (PCa) risk. To test the hypothesis that other sequence variants in the genome may interact with those 32 known PCa risk-associated SNPs identified from GWAS to affect PCa risk, we performed a systematic evaluation among three existing PCa GWAS populations: CAncer of the...
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