Article
Human polymorphisms at long non-coding RNAs (lncRNAs) and association with prostate cancer risk.
Carcinogenesis - 1 Nov 2011
Jin Guangfu, Sun Jielin, Isaacs Sarah D, Wiley Kathleen E, Kim Seong-Tae, Chu Lisa W, Zhang Zheng, Zhao Hui, Zheng Siqun Lilly, Isaacs William B, Xu Jianfeng
Abstract excerpt
Long non-coding RNAs (lncRNAs), representing a large proportion of non-coding transcripts across the human genome, are evolutionally conserved and biologically functional. At least one-third of the phenotype-related loci identified by genome-wide association studies (GWAS) are mapped to non-coding intervals. However, the relationships between phenotype-related loci and lncRNAs are largely unknown. Utilizing the...
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