Large-scale exploration of gene-gene interactions in prostate cancer using a multistage genome-wide association study.

doi:10.1158/0008-5472.CAN-10-2646

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Article

Large-scale exploration of gene-gene interactions in prostate cancer using a multistage genome-wide association study.

Cancer research - 1 May 2011

Ciampa Julia, Yeager Meredith, Amundadottir Laufey, Jacobs Kevin, Kraft Peter, Chung Charles, Wacholder Sholom, Yu Kai, Wheeler William, Thun Michael J, Divers W Ryan, Gapstur Susan, Albanes Demetrius, Virtamo Jarmo, Weinstein Stephanie, Giovannucci Edward, Willett Walter C, Cancel-Tassin Geraldine, Cussenot Olivier, Valeri Antoine, Hunter David, Hoover Robert, Thomas Gilles, Chanock Stephen, Chatterjee Nilanjan

Abstract excerpt

Recent genome-wide association studies have identified independent susceptibility loci for prostate cancer that could influence risk through interaction with other, possibly undetected, susceptibility loci. We explored evidence of interaction between pairs of 13 known susceptibility loci and single nucleotide polymorphisms (SNP) across the genome to generate hypotheses about the functionality of prostate cancer...

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Identifiers

PMID: 21372204
DOI: 10.1158/0008-5472.CAN-10-2646
PMCID: PMC3085580

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EPAS1
KLK2
KLK3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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