Article
Deciphering the genetic background of systemic sclerosis.
Expert review of clinical immunology - 1 Jul 2011
Broen Jasper C A, Coenen Marieke J H, Radstake Timothy R D J
Abstract excerpt
Systemic sclerosis (SSc) is a severe autoimmune connective tissue disease. Over the years, evidence for a genetic background of SSc susceptibility has clearly accumulated. This article aims to provide an extensive overview of genetics in SSc research. We discuss indicators for a genetic component present in SSc, family studies, chromosomal aberrances, the involvement of the HLA region and multiple candidate genes...
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