Article
Population genetic analysis of the uncoupling proteins supports a role for UCP3 in human cold resistance.
Molecular biology and evolution - 1 Jan 2011
Hancock Angela M, Clark Vanessa J, Qian Yudong, Di Rienzo Anna
Abstract excerpt
Production of heat via nonshivering thermogenesis (NST) is critical for temperature homeostasis in mammals. Uncoupling protein UCP1 plays a central role in NST by uncoupling the proton gradients produced in the inner membranes of mitochondria to produce heat; however, the extent to which UCP1 homologues, UCP2 and UCP3, are involved in NST is the subject of an ongoing debate. We used an evolutionary approach to...
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