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Article

Mutant TP53 G245C and R273H promote cellular malignancy in esophageal squamous cell carcinoma.

BMC cell biology - 20 Aug 2018

Kang Nan, Wang Yu, Guo Shichao, Ou Yunwei, Wang Guangchao, Chen Jie, Li Dan, Zhan Qimin

Abstract excerpt

BACKGROUND: TP53 gene mutations occur in more than 50% of human cancers and the vast majority of these mutations in human cancers are missense mutations, which broadly occur in DNA binding domain (DBD) (Amino acids 102-292) and mainly reside in six "hotspot" residues. TP53 G245C and R273H point mutations are two of the most frequent mutations in tumors and have been verified in several different cancers. In the...

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Identifiers

PMID: 30126368
DOI: 10.1186/s12860-018-0167-y
PMCID: PMC6102840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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