Article
IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma.
Blood - 23 Feb 2012
Cairns Rob A, Iqbal Javeed, Lemonnier François, Kucuk Can, de Leval Laurence, Jais Jean-Philippe, Parrens Marie, Martin Antoine, Xerri Luc, Brousset Pierre, Chan Li Chong, Chan Wing-Chung, Gaulard Philippe, Mak Tak W
Abstract excerpt
Mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) occur in most grade 2 and 3 gliomas, secondary glioblastomas, and a subset of acute myelogenous leukemias but have not been detected in other tumor types. The mutations occur at specific arginine residues and result in the acquisition of a novel enzymatic activity that converts 2-oxoglutarate to D-2-hydroxyglutarate. This study...
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